High-TECh thymus.
نویسنده
چکیده
ased assessment of associations with disease phenotypes. This approach relieves the investigator of having to conjure up candidate genes, and will lead to unexpected and often inexplicable findings, as have been reported for diabetes, a prime example of a multigenic trait.3 To query such a large number of SNPs, patient samples must be substantial and the analytical approach must be rigorous. Nevertheless, many smaller studies could be aggregated to provide a patient base that is sufficiently large and diverse to validate the findings. The near-term results of these studies will be an additional means of predicting outcomes and tailoring treatment. A longer-term goal is the identification of hitherto unsuspected disease modulators, like the TGF/BMP pathway, that might be amenable to modulation and therefore suggest new avenues of drug development. Conflict-of-interest disclosure: The author declares no competing financial interests. ■
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ورودعنوان ژورنال:
- Blood
دوره 111 12 شماره
صفحات -
تاریخ انتشار 2008